Catalytic Enantioselective Cr-Mediated Propargylation: Application to Halichondrin Synthesis

Author:

Liu Songbai1,Kim Joseph T.1,Dong Cheng-Guo1,Kishi Yoshito1

Affiliation:

1. Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference36 articles.

1. Total synthesis of halichondrin B and norhalichondrin B

2. For isolation and synthesis on the halichondrins, see refs1−3in the preceding paper:Yang, Y.R.; Kim, D.S.; Kishi, Y.Org. Lett.2009,11, (DOI10.1021/ol9016589).

3. For discovery and development of E7389, see ref5in ref2.

4. For reviews on Cr-mediated carbon−carbon bond-forming reactions, see:

5. aSaccomano, N. A.InComprehensive Organic Synthesis;Trost, B. M.; Fleming, I., Eds.Pergamon:Oxford, 1991; Vol. 1, p173.

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