1. Total synthesis of halichondrin B and norhalichondrin B
2. For isolation and synthesis on the halichondrins, see refs1−3in the preceding paper:Yang, Y.R.; Kim, D.S.; Kishi, Y.Org. Lett.2009,11, (DOI10.1021/ol9016589).
3. For discovery and development of E7389, see ref5in ref2.
4. For reviews on Cr-mediated carbon−carbon bond-forming reactions, see:
5. aSaccomano, N. A.InComprehensive Organic Synthesis;Trost, B. M.; Fleming, I., Eds.Pergamon:Oxford, 1991; Vol. 1, p173.