Comparative Antimalarial Activities and ADME Profiles of Ozonides (1,2,4-trioxolanes) OZ277, OZ439, and Their 1,2-Dioxolane, 1,2,4-Trioxane, and 1,2,4,5-Tetraoxane Isosteres-Reference-Cited by-同舟云学术

Comparative Antimalarial Activities and ADME Profiles of Ozonides (1,2,4-trioxolanes) OZ277, OZ439, and Their 1,2-Dioxolane, 1,2,4-Trioxane, and 1,2,4,5-Tetraoxane Isosteres

Published:2013-03-15 Issue:6 Volume:56 Page:2547-2555
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Xiaofang¹,Dong Yuxiang¹,Wittlin Sergio²³,Charman Susan A.⁴,Chiu Francis C. K.⁴,Chollet Jacques²³,Katneni Kasiram⁴,Mannila Janne⁴,Morizzi Julia⁴,Ryan Eileen⁴,Scheurer Christian²³,Steuten Jessica⁴,Santo Tomas Josefina²³,Snyder Christopher²³,Vennerstrom Jonathan L.¹

Affiliation:

1. College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, Nebraska, United States

2. Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland

3. University of Basel, CH-4003 Basel, Switzerland

4. Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm400004u

Reference44 articles.

1. From Artemisinin to New Artemisinin Antimalarials: Biosynthesis, Extraction, Old and New Derivatives, Stereochemistry and Medicinal Chemistry Requirements

2. Qinghaosu (Artemisinin): The Price of Success

3. New developments in synthetic peroxidic drugs as artemisinin mimics

4. Progress in the development of peroxide-based anti-parasitic agents

5. Synthetic peroxides as antimalarials

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