Discovery of Novel Quaternary Ammonium Derivatives of (3R)-Quinuclidinol Esters as Potent and Long-Acting Muscarinic Antagonists with Potential for Minimal Systemic Exposure after Inhaled Administration: Identification of (3R)-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane Bromide (Aclidinium Bromide)-Reference-Cited by-同舟云学术

Discovery of Novel Quaternary Ammonium Derivatives of (3R)-Quinuclidinol Esters as Potent and Long-Acting Muscarinic Antagonists with Potential for Minimal Systemic Exposure after Inhaled Administration: Identification of (3R)-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane Bromide (Aclidinium Bromide)

Published:2009-08-04 Issue:16 Volume:52 Page:5076-5092
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Prat María¹,Fernández Dolors¹,Buil M. Antonia¹,Crespo María I.¹,Casals Gaspar¹,Ferrer Manuel¹,Tort Laia¹,Castro Jordi¹,Monleón Juan M.¹,Gavaldà Amadeu¹,Miralpeix Montserrat¹,Ramos Israel¹,Doménech Teresa¹,Vilella Dolors¹,Antón Francisca¹,Huerta Josep M.¹,Espinosa Sonia¹,López Manuel¹,Sentellas Sonia¹,González Marisa¹,Albertí Joan¹,Segarra Victor¹,Cárdenas Alvaro¹,Beleta Jorge¹,Ryder Hamish¹

Affiliation:

1. Almirall, R&D Centre, Sant Feliu de Llobregat, Barcelona, Spain

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900132z

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