Ketoconazole-p-aminobenzoic Acid Cocrystal: Revival of an Old Drug by Crystal Engineering

Author:

Martin Flavia1,Pop Mihaela2ORCID,Kacso Irina1,Grosu Ioana Georgeta1,Miclăuş Maria1,Vodnar Dan3,Lung Ildiko4,Filip Gabriela Adriana5,Olteanu Elena Diana5,Moldovan Remus5,Nagy Andras6,Filip Xenia1ORCID,Bâldea Ioana5

Affiliation:

1. Molecular and Biomolecular Physics Department, National Institute for R&D of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, Romania

2. TeraCrystal, 67-103 Donat, 400293 Cluj-Napoca, Romania

3. Department of Food Science, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Mănăştur 3-5, 400372 Cluj-Napoca, Romania

4. Physics of Nanostructured Systems, National Institute for R&D of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, Romania

5. Department of Physiology, Iuliu Haţieganu University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, Romania

6. Department of Toxicology, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Mănăştur 3-5, 400372 Cluj-Napoca, Romania

Funder

Autoritatea Nationala pentru Cercetare Stiintifica

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Reference61 articles.

1. Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision

2. History of the development of azole derivatives

3. European Medicines Agency. European Medicines Agency recommends suspension of marketing authorisations for oral ketoconazole. https://www.ema.europa.eu/en/news/european-medicines-agency-recommends-suspension-marketing-authorisations-oral-ketoconazole, 2013.

4. FDA Drug Safety Communication: FDA limits usage of Nizoral (ketoconazole) oral tablets due to potentially fatal liver injury and risk of drug interactions and adrenal gland problems. http://www.fda.gov/Drugs/DrugSafety/ucm362415.htm, 2013.

5. Ketoconazole in Cushing's Disease: Is It Worth a Try?

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