Synergistic Nanomedicine Delivering Topoisomerase I Toxin (SN-38) and Inhibitors of Polynucleotide Kinase 3′-Phosphatase (PNKP) for Enhanced Treatment of Colorectal Cancer-Reference-Cited by-同舟云学术

Synergistic Nanomedicine Delivering Topoisomerase I Toxin (SN-38) and Inhibitors of Polynucleotide Kinase 3′-Phosphatase (PNKP) for Enhanced Treatment of Colorectal Cancer

Published:2024-05-24 Issue:7 Volume:21 Page:3240-3255
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Sadat Sams M. A.¹^ORCID,Vakili Mohammad Reza¹,Abd-El Hafeez Sara I.¹²,Paladino Marco³,Hall Dennis G.³^ORCID,Weinfeld Michael⁴^ORCID,Lavasanifar Afsaneh¹⁵^ORCID

Affiliation:

1. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2R3, Canada

2. Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt

3. Department of Chemistry, Faculty of Science, University of Alberta, Edmonton, Alberta T6G 2R3, Canada

4. Department of Oncology, Cross Cancer Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R3, Canada

5. Department of Chemical and Material Engineering, University of Alberta, Edmonton, Alberta T6G 2R3, Canada

Funder

Canadian Institutes of Health Research

Alberta Cancer Foundation

Ministry of Higher Education and Scientific Research

NanoMedicines Innovation Network

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.4c00007

Reference24 articles.

1. CPX-351 (vyxeos) in AML

2. Nanoencapsulation of Novel Inhibitors of PNKP for Selective Sensitization to Ionizing Radiation and Irinotecan and Induction of Synthetic Lethality

3. Identification of a Small Molecule Inhibitor of the Human DNA Repair Enzyme Polynucleotide Kinase/Phosphatase

4. Challenges in SN38 drug delivery: current success and future directions

5. A new UPLC-MS/MS method for the determination of irinotecan and 7-ethyl-10-hydroxycamptothecin (SN-38) in mice: Application to plasma and brain pharmacokinetics