Thiolation of Q295: Site-Specific Conjugation of Hydrophobic Payloads without the Need for Genetic Engineering
Author:
Affiliation:
1. School of Pharmacy and Pharmaceutical Sciences, Binghamton University, P.O. Box 6000, Binghamton, New York 13902, United States
Funder
SUNY research foundation
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.9b00323
Reference53 articles.
1. Drawing lessons from the clinical development of antibody-drug conjugates
2. A phase 1, dose-escalation study of PF-06664178, an anti-Trop-2/Aur0101 antibody-drug conjugate in patients with advanced or metastatic solid tumors
3. Investigational CD33-targeted therapeutics for acute myeloid leukemia
4. AbbVie takes $4B hit on Rova-T failures | FierceBiotech https://www.fiercebiotech.com/biotech/abbvie-takes-4b-hit-rova-t-failures (accessed Feb 18, 2019).
5. Preclinical studies of a Pro-antibody-drug conjugate designed to selectively target EGFR-overexpressing tumors with improved therapeutic efficacy
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