A Food Effect Study of an Oral Thrombin Inhibitor and Prodrug Approach To Mitigate It-Reference-Cited by-同舟云学术

A Food Effect Study of an Oral Thrombin Inhibitor and Prodrug Approach To Mitigate It

Published:2016-03-01 Issue:4 Volume:13 Page:1197-1205
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Lee Jihye¹,Kim Bongchan²,Kim Tae Hun²,Lee Sun Hwa²,Park Hee Dong²,Chung Kyungha²,Lee Sung-Hack²,Paek Seungyup²,Kim Eunice EunKyeong³,Yoon SukKyoon⁴,Kim Aeri¹

Affiliation:

1. College of Pharmacy, CHA University, 521 CHA Bio Complex, 335 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13488, Korea

2. LG Life Sciences, R&D Center,188, Munji-ro, Yuseong-gu, Daejeon 34122, Korea

3. Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, Korea

4. New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 41061 Daegu, Korea

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.5b00637

Reference25 articles.

1. Efficacious and Orally Bioavailable Thrombin Inhibitors Based on a 2,5-Thienylamidine at the P1 Position: Discovery of N-Carboxymethyl-d-diphenylalanyl-l-prolyl[(5-amidino-2-thienyl)methyl]amide

2. Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrug

3. Pharmacokinetics and dose-dependency of LB30870 in rats, dogs, and monkeys

4. Pharmacokinetics, pharmacodynamics and food effect of LB30870, a novel direct thrombin inhibitor, after single oral doses in healthy men

5. Factor Xa and thrombin as targets for new oral anticoagulants

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