Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging

Author:

Clitherow Katharina H.1,Murdoch Craig1ORCID,Spain Sebastian Guy2ORCID,Handler Anna Mette3,Colley Helen E.1,Stie Mai Bay3,Mørck Nielsen Hanne3ORCID,Janfelt Christian3ORCID,Hatton Paul V.1ORCID,Jacobsen Jette3

Affiliation:

1. School of Clinical Dentistry, University of Sheffield, 19 Claremont Crescent, Sheffield S10 2TA, U.K.

2. Department of Chemistry, University of Sheffield, Brook Hill, Sheffield S3 7HF, U.K.

3. Department of Pharmacy, University of Copenhagen, 2 Universitetsparken, Copenhagen DK-2100, Denmark

Funder

Engineering and Physical Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Reference48 articles.

1. Medicines Optimisation in Long-Term Pain|Guidance and Guidelines|NICE. https://www.nice.org.uk/advice/ktt21/chapter/Evidence-context (accessed Jan 14, 2019).

2. Managing Pharyngeal and Oral Mucosal Pain

3. Complications of Radiation Therapy for Head and Neck Cancers

4. Anxiety and pain during dental injections

5. Preparation and Characterization of Lidocaine Double Layer Buccal Tablet Using Mucoadhesive Carbopol® Polymers

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