Identification of Natural Compound Radicicol as a Potent FTO Inhibitor
Author:
Affiliation:
1. School of Life Sciences, Tsinghua University, and Tsinghua-Peking Center for Life Sciences, Beijing 100084, China
2. College of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China
Funder
Natural Science Foundation of Henan Province
National Natural Science Foundation of China
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.8b00522
Reference45 articles.
1. The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition
2. The FTO Obesity Gene. Genotyping and Gene Expression Analysis in Morbidly Obese Patients
3. Inactivation of the Fto gene protects from obesity
4. N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
5. N6-methyladenosine marks primary microRNAs for processing
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