In Silico, In Vitro, and In Vivo Evaluation of Precipitation Inhibitors in Supersaturated Lipid-Based Formulations of Venetoclax-Reference-Cited by-同舟云学术

In Silico, In Vitro, and In Vivo Evaluation of Precipitation Inhibitors in Supersaturated Lipid-Based Formulations of Venetoclax

Published:2021-04-23 Issue:6 Volume:18 Page:2174-2188
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Koehl Niklas J.¹²^ORCID,Henze Laura J.¹³,Bennett-Lenane Harriet¹,Faisal Waleed¹⁴,Price Daniel J.⁵⁶,Holm René²⁷⁸,Kuentz Martin⁹^ORCID,Griffin Brendan T.¹^ORCID

Affiliation:

1. School of Pharmacy, University College Cork, College Road, T12 YN60 Cork, Ireland

2. Drug Product Development, Janssen Research and Development, Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium

3. Analytical Development, Janssen Research and Development, Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium

4. Faculty of Pharmacy, Minia University, Minia, Egypt

5. Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany

6. Institution of Pharmaceutical Technology, Goethe University Frankfurt, Max-von-Laue-Strasse 9, 60439 Frankfurt am Main, Germany

7. Department of Science and Environment, Roskilde University, 4000 Roskilde, Denmark

8. Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark

9. Institute of Pharma Technology, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, 4132 Muttenz, Switzerland

Funder

H2020 Marie Sklodowska-Curie Actions

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.0c00645

Reference54 articles.

1. Computational prediction of formulation strategies for beyond-rule-of-5 compounds

2. Beyond the Rule of 5: Lessons Learned from AbbVie’s Drugs and Compound Collection

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