Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody

Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody–Drug Conjugates

Published:2018-07-24 Issue:9 Volume:15 Page:3979-3996
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Pei Zhonghua¹,Chen Chunjiao²,Chen Jinhua³,Cruz-Chuh Josefa dela¹,Delarosa Reginald¹,Deng Yuzhong¹,Fourie-O’Donohue Aimee¹,Figueroa Isabel¹,Guo Jun¹,Jin Weiwei²,Khojasteh S. Cyrus¹,Kozak Katherine R.¹,Latifi Brandon¹,Lee James¹,Li Guangmin¹,Lin Eva¹,Liu Liling¹,Lu Jiawei²,Martin Scott¹,Ng Carl¹,Nguyen Trung¹,Ohri Rachana¹,Lewis Phillips Gail¹,Pillow Thomas H.¹,Rowntree Rebecca K.¹,Stagg Nicola J.¹,Stokoe David¹,Ulufatu Sheila¹,Verma Vishal A.¹,Wai John³,Wang Jing³,Xu Keyang¹,Xu Zijin³,Yao Hui³,Yu Shang-Fan¹,Zhang Donglu¹^ORCID,Dragovich Peter S.¹^ORCID

Affiliation:

1. Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. WuXi Biologics, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China

3. Wuxi Apptec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.8b00431

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