Drug Release and Nanodroplet Formation from Amorphous Solid Dispersions: Insight into the Roles of Drug Physicochemical Properties and Polymer Selection
Author:
Affiliation:
1. Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States
2. Merck & Co., Inc. 2000, Galloping Hill Road, Kenilworth, New Jersey 07033, United States
Funder
Agency for Science, Technology and Research
Merck
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.1c00055
Reference71 articles.
1. Strategies to Address Low Drug Solubility in Discovery and Development
2. Fundamental aspects of solid dispersion technology for poorly soluble drugs
3. Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery – An update
4. Assessment of the Amorphous “Solubility” of a Group of Diverse Drugs Using New Experimental and Theoretical Approaches
5. Solubility advantage of amorphous pharmaceuticals: I. A thermodynamic analysis
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