Quantifying Molecular Mixing and Heterogeneity in Pharmaceutical Dispersions at Sub-100 nm Resolution by Spin Diffusion NMR-Reference-Cited by-同舟云学术

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Quantifying Molecular Mixing and Heterogeneity in Pharmaceutical Dispersions at Sub-100 nm Resolution by Spin Diffusion NMR

Published:2020-07-31 Issue:9 Volume:17 Page:3567-3580
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Duan Pu¹^ORCID,Lamm Matthew S.²,Yang Fengyuan²,Xu Wei²,Skomski Daniel²,Su Yongchao²³⁴^ORCID,Schmidt-Rohr Klaus¹^ORCID

Affiliation:

1. Department of Chemistry, Brandeis University, Waltham, Massachusetts 02453, United States

2. Pharmaceutical Sciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

3. Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States

4. Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, United States

Funder

Merck

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.0c00592

Reference65 articles.

1. Pharmaceutical applications of cyclodextrins: basic science and product development

2. The use of amorphous solid dispersions: A formulation strategy to overcome poor solubility and dissolution rate

3. Studies on Absorption of Eutectic Mixture. II. Absorption of fused Conglomerates of Chloramphenicol and Urea in Rabbits.

4. Solubility of Small-Molecule Crystals in Polymers: d-Mannitol in PVP, Indomethacin in PVP/VA, and Nifedipine in PVP/VA

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