Validation of Early Human Dose Prediction: A Key Metric for Compound Progression in Drug Discovery
Author:
Affiliation:
1. Drug Safety and Metabolism, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.5b00840
Reference44 articles.
1. Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985).
2. Can the pharmaceutical industry reduce attrition rates?
3. Discovery DMPK: changing paradigms in the eighties, nineties and noughties
4. Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics
5. ADME/PK as part of a rational approach to drug discovery
Cited by 55 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Application of Mechanistic Multiparameter Optimization and Large-Scale In Vitro to In Vivo Pharmacokinetics Correlations to Small-Molecule Therapeutic Projects;Molecular Pharmaceutics;2024-08-13
2. Novel hydrazone compounds with broad-spectrum antiplasmodial activity and synergistic interactions with antimalarial drugs;Antimicrobial Agents and Chemotherapy;2024-04-19
3. Application of mechanistic multiparameter optimization and large scale in vitro toin vivopharmacokinetics correlations to small molecule therapeutic projects;2024-03-11
4. Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson’s Disease;Journal of Medicinal Chemistry;2023-10-20
5. Application of Physiologically Based Pharmacokinetic Modeling to Predict Drug–Drug Interactions between Elexacaftor/Tezacaftor/Ivacaftor and Tacrolimus in Lung Transplant Recipients;Pharmaceutics;2023-05-08
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3