Improving Oral Bioavailability of Sorafenib by Optimizing the “Spring” and “Parachute” Based on Molecular Interaction Mechanisms-Reference-Cited by-同舟云学术

Improving Oral Bioavailability of Sorafenib by Optimizing the “Spring” and “Parachute” Based on Molecular Interaction Mechanisms

Published:2016-01-06 Issue:2 Volume:13 Page:599-608
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Liu Chengyu¹,Chen Zhen¹,Chen Yuejie¹,Lu Jia²,Li Yuan²,Wang Shujing¹,Wu Guoliang¹,Qian Feng¹

Affiliation:

1. School of Pharmaceutical Sciences and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Tsinghua University, Beijing 100084, China

2. College of Pharmaceutical Sciences, Soochow University, Suzhou 215006, China

Funder

National Natural Science Foundation of China

Central Committee of the Communist Party of China

Center for Life Sciences

Beijing Municipal Science and Technology Commission

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.5b00837

Reference34 articles.

1. Discovery and development of sorafenib: a multikinase inhibitor for treating cancer

2. Sorafenib Blocks the RAF/MEK/ERK Pathway, Inhibits Tumor Angiogenesis, and Induces Tumor Cell Apoptosis in Hepatocellular Carcinoma Model PLC/PRF/5

3. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling

4. CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations

5. US Food and Drug Administration. Sorafenib (Nexavar) prescribing information ( 2005) .

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