Functional Characterization of Six SLCO1B1 (OATP1B1) Variants Observed in Finnish Individuals with a Psychotic Disorder

Author:

Häkkinen Katja12ORCID,Kiander Wilma3,Kidron Heidi3ORCID,Lähteenvuo Markku1,Urpa Lea2ORCID,Lintunen Jonne1ORCID,Vellonen Kati-Sisko4,Auriola Seppo4,Holm Minna5,Lahdensuo Kaisla6,Kampman Olli7891011,Isometsä Erkki12,Kieseppä Tuula512,Lönnqvist Jouko513,Suvisaari Jaana5ORCID,Hietala Jarmo14,Tiihonen Jari1151617,Palotie Aarno21819,Ahola-Olli Ari V.21820,Niemi Mikko212223ORCID

Affiliation:

1. Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, Kuopio FI-70240, Finland

2. Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki FI-00014, Finland

3. Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki FI-00014, Finland

4. School of Pharmacy, University of Eastern Finland, Kuopio FI-70211, Finland

5. Mental Health Team, Finnish Institute for Health and Welfare, Helsinki FI-00271, Finland

6. Mehiläinen Ltd, Helsinki FI-00260, Finland

7. Faculty of Medicine and Health Technology, Tampere University, Tampere FI-33100, Finland

8. Department of Psychiatry, Pirkanmaa Hospital District, Tampere FI-33521, Finland

9. Department of Clinical Sciences (Psychiatry), Faculty of Medicine, Umeå University, Umeå SE-90187, Sweden

10. Department of Psychiatry, University Hospital of Umeå, Umeå SE-90187, Sweden

11. Department of Clinical Medicine (Psychiatry), Faculty of Medicine, University of Turku, Turku FI-20014, Finland

12. Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki FI-00014, Finland

13. Department of Psychiatry, University of Helsinki, Helsinki FI-00014, Finland

14. Department of Psychiatry, University of Turku and Turku University Hospital, Turku FI-20700, Finland

15. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm SE-17177, Sweden

16. Center for Psychiatry Research, Stockholm City Council, Stockholm SE-11364, Sweden

17. Neuroscience Center, University of Helsinki, Helsinki FI-00014, Finland

18. The Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States

19. Analytic and Translational Genetics Unit, Department of Medicine, Department of Neurology and Department of Psychiatry, Massachusetts General Hospital, Boston MA-02114, United States

20. Department of Internal Medicine, Satasairaala Hospital, Pori FI-28500, Finland

21. Department of Clinical Pharmacology, University of Helsinki, Helsinki FI-00014, Finland

22. Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki, Helsinki FI-00014, Finland

23. Department of Clinical Pharmacology, HUS Diagnostic Center, Helsinki University Hospital, Helsinki FI-00029, Finland

Funder

Emil Aaltosen S??ti?

Biocenter Finland

Orionin Tutkimuss??ti?

Kela

Yrj? Jahnssonin S??ti?

Academy of Finland

Sosiaali- ja Terveysministeri?

Suomen L??ketieteen S??ti?

Juho Vainion S??ti?

H2020 European Research Council

Broad Institute

Suomen Kulttuurirahasto

Finnish Post Doc Pool

Finnish Foundation for Psychiatric Research

Biocenter Kuopio

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

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