Drug–Polymer Interactions in Acetaminophen/Hydroxypropylmethylcellulose Acetyl Succinate Amorphous Solid Dispersions Revealed by Multidimensional Multinuclear Solid-State NMR Spectroscopy-Reference-Cited by-同舟云学术

Drug–Polymer Interactions in Acetaminophen/Hydroxypropylmethylcellulose Acetyl Succinate Amorphous Solid Dispersions Revealed by Multidimensional Multinuclear Solid-State NMR Spectroscopy

Published:2021-08-10 Issue:9 Volume:18 Page:3519-3531
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Pugliese Andrea¹^ORCID,Toresco Michael²,McNamara Daniel³^ORCID,Iuga Dinu⁴,Abraham Anuji³,Tobyn Michael⁵,Hawarden Lucy E.⁵,Blanc Frédéric¹⁶^ORCID

Affiliation:

1. Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, United Kingdom

2. Chemical Engineering Department, Rowan College of Engineering, Rowan University, Mullica Hill Road, Glassboro, New Jersey 08028, United States

3. Drug Product Development, Bristol-Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08903, United States

4. Department of Physics, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom

5. Drug Product Development, Bristol-Myers Squibb, Reeds Lane, Moreton CH46 1QW, United Kingdom

6. Stephenson Institute for Renewable Energy, University of Liverpool, Peach Street, Liverpool L69 7ZF, United Kingdom

Funder

Engineering and Physical Sciences Research Council

European Regional Development Fund

Advantage West Midlands

Bristol-Myers Squibb

Biotechnology and Biological Sciences Research Council

University of Warwick

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.1c00427

Reference80 articles.

1. Better understanding of dissolution behaviour of amorphous drugs by in situ solid-state analysis using Raman spectroscopy

2. Improving drug solubility for oral delivery using solid dispersions

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