Aggregation Behavior of Structurally Similar Therapeutic Peptides Investigated by <sup>1</sup>H NMR and All-Atom Molecular Dynamics Simulations-Reference-Cited by-同舟云学术

Aggregation Behavior of Structurally Similar Therapeutic Peptides Investigated by ¹H NMR and All-Atom Molecular Dynamics Simulations

Published:2022-02-01 Issue:3 Volume:19 Page:904-917
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Hjalte Johanna¹^ORCID,Hossain Shakhawath²^ORCID,Hugerth Andreas³^ORCID,Sjögren Helen³^ORCID,Wahlgren Marie¹^ORCID,Larsson Per²^ORCID,Lundberg Dan⁴^ORCID

Affiliation:

1. Food Technology, Engineering and Nutrition, Lund University, Box 124, 221 00 Lund, Sweden

2. Department of Pharmacy, Drug Delivery, Uppsala University, Box 580, 751 23 Uppsala, Sweden

3. Ferring Pharmaceuticals A/S, Amager Strandvej 405, 2770 Kastrup, Denmark

4. CR Competence AB, Center for Chemistry and Chemical Engineering, Box 124, 221 00 Lund, Sweden

Funder

VINNOVA

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.1c00883

Reference52 articles.

1. Physicochemical and Formulation Developability Assessment for Therapeutic Peptide Delivery—A Primer

2. Peptide Optimization at the Drug Discovery-Development Interface: Tailoring of Physicochemical Properties Toward Specific Formulation Requirements

3. Peptide therapeutics: current status and future directions

4. Therapeutic peptides: Historical perspectives, current development trends, and future directions

5. Factors affecting the physical stability (aggregation) of peptide therapeutics

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