Pharmacokinetic Modeling of (R)-[11C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates-Reference-Cited by-同舟云学术

Pharmacokinetic Modeling of (R)-[11C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates

Published:2020-12-14 Issue:1 Volume:18 Page:416-428
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

García-Varela Lara¹^ORCID,García David Vállez¹,Kakiuchi Takeharu²,Ohba Hiroyuki²,Nishiyama Shingo²,Tago Tetsuro³^ORCID,Elsinga Philip H.¹,Tsukada Hideo²,Colabufo Nicola A.⁴⁵^ORCID,Dierckx Rudi A.J.O.¹,van Waarde Aren¹,Toyohara Jun³,Boellaard Ronald¹,Luurtsema Gert¹

Affiliation:

1. Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30001, Groningen 9713 GZ, The Netherlands

2. Central Research Laboratory, Hamamatsu Photonics KK, 5000 Hirakuchi, Hamakita, Hamamatsu 434-8601, Shizuoka, Japan

3. Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan

4. Department of Pharmacy, University of Bari Aldo Moro, Bari 70125, Italy

5. Biofordrug, Spin-off Università degli Studi di Bari “A. Moro”, via Dante 99, Triggiano, Bari 70019, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.0c01014

Reference57 articles.

1. Verapamil

2. In vivo measurement of [11C]verapamil kinetics in human tissues

3. Structure and function of ABC transporters: the ATP switch provides flexible control

4. Structure and function of the blood–brain barrier

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4. Head-to-head comparison of (R)-[11C]verapamil and [18F]MC225 in non-human primates, tracers for measuring P-glycoprotein function;European Journal of Nuclear Medicine and Molecular Imaging;2021-06-11