Adding a Gastric Step to the Intestinal In Vitro Digestion Model Improves the Prediction of Pharmacokinetic Data in Beagle Dogs of Two Lipid-Based Drug Delivery Systems-Reference-Cited by-同舟云学术

Adding a Gastric Step to the Intestinal In Vitro Digestion Model Improves the Prediction of Pharmacokinetic Data in Beagle Dogs of Two Lipid-Based Drug Delivery Systems

Published:2020-07-14 Issue:9 Volume:17 Page:3214-3222
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Klitgaard Mette¹,Beilles Stephane²,Sassene Philip Jonas¹,Berthelsen Ragna¹,Müllertz Anette¹³^ORCID

Affiliation:

1. Department of Pharmacy, University of Copenhagen, Copenhagen 2100, Denmark

2. Pharmaceutical Science Department, Sanofi, Montpellier 34080, France

3. Bioneer:FARMA, Department of Pharmacy, University of Copenhagen, Copenhagen 1165, Denmark

Funder

Innovative Medicines Initiative

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.0c00307

Reference30 articles.

1. Intestinal solubility and absorption of poorly water soluble compounds: predictions, challenges and solutions

2. In vitro models for the prediction of in vivo performance of oral dosage forms

3. Formulation of lipid-based delivery systems for oral administration: Materials, methods and strategies

4. Impact of gastrointestinal lipolysis on oral lipid-based formulations and bioavailability of lipophilic drugs

5. Lipid-based vehicles for the oral delivery of poorly water soluble drugs

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