Site-Specific Hydrolysis Reaction C-Terminal of Methionine in Met-His during Metal-Catalyzed Oxidation of IgG-1-Reference-Cited by-同舟云学术

Site-Specific Hydrolysis Reaction C-Terminal of Methionine in Met-His during Metal-Catalyzed Oxidation of IgG-1

Published:2016-03-11 Issue:4 Volume:13 Page:1317-1328
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Mozziconacci Olivier¹,Arora Jayant¹,Toth Ronald T.¹,Joshi Sangeeta B.¹,Zhou Shuxia²,Volkin David B.¹,Schöneich Christian¹

Affiliation:

1. Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, United States

2. Drug Product Development, Pharmaceutical Development and Manufacturing Sciences, Janssen Research & Development, LLC, Malvern, Pennsylvania 19355, United States

Funder

Janssen Research and Development

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.5b00944

Reference51 articles.

1. Stability of Protein Pharmaceuticals: An Update

2. Spontaneous degradation of polypeptides at aspartyl and asparaginyl residues: Effects of the solvent dielectric

3. Effect of N-1 and N-2 residues on peptide deamidation rate in solution and solid state

4. The oxidative environment and protein damage

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