Insulin Signaling Differentially Regulates the Trafficking of Insulin and Amyloid Beta Peptides at the Blood

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Insulin Signaling Differentially Regulates the Trafficking of Insulin and Amyloid Beta Peptides at the Blood–Brain Barrier

Published:2024-04-16 Issue:5 Volume:21 Page:2176-2186
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Zhou Andrew L.¹^ORCID,Swaminathan Suresh K.¹,Salian Vrishali S.¹,Wang Lushan¹,Curran Geoffry L.²³,Min Hoon-Ki²,Lowe Val J.²,Kandimalla Karunya K.¹^ORCID

Affiliation:

1. Department of Pharmaceutics and Brain Barriers Research Center, University of Minnesota College of Pharmacy, Minneapolis, Minnesota 55455, United States

2. Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, United States

3. Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, United States

Funder

National Institute of Neurological Disorders and Stroke

Minnesota Partnership for Biotechnology and Medical Genomics

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.3c00784

Reference50 articles.

1. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

2. Aβ42 and Aβ40: similarities and differences

3. A 40 Inhibits Amyloid Deposition In Vivo

4. Amyloid β Protein: Aβ40 Inhibits Aβ42 Oligomerization

5. RAGE (Yin) Versus LRP (Yang) Balance Regulates Alzheimer Amyloid β-Peptide Clearance Through Transport Across the Blood–Brain Barrier

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