Extensive Chemical Modifications in the Primary Protein Structure of IgG1 Subvisible Particles Are Necessary for Breaking Immune Tolerance-Reference-Cited by-同舟云学术

Extensive Chemical Modifications in the Primary Protein Structure of IgG1 Subvisible Particles Are Necessary for Breaking Immune Tolerance

Published:2017-03-07 Issue:4 Volume:14 Page:1292-1299
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Boll Björn¹²,Bessa Juliana³,Folzer Emilien¹⁴²,Ríos Quiroz Anacelia¹²^ORCID,Schmidt Roland⁴,Bulau Patrick⁵,Finkler Christof¹,Mahler Hanns-Christian⁴,Huwyler Jörg²,Iglesias Antonio³,Koulov Atanas V.¹

Affiliation:

1. Analytical Development & Quality Control, Pharma Technical Development Biologics Europe, F. Hoffmann-La Roche Ltd., Basel, Switzerland

2. Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

3. Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland

4. Pharmaceutical Development & Supplies, Pharma Technical Development Biologics Europe, F. Hoffmann-La Roche Ltd., Basel, Switzerland

5. Analytical Development & Quality Control, Pharma Technical Development Biologics Europe, Roche Diagnostics GmbH, Penzberg, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.6b00816

Reference33 articles.

1. Protein aggregation: Pathways, induction factors and analysis

2. Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development

3. Protein aggregation: Pathways, induction factors and analysis

4. Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development

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