Impact of Ferroquine on the Solubilization of Artefenomel (OZ439) during in Vitro Lipolysis in Milk and Implications for Oral Combination Therapy for Malaria-Reference-Cited by-同舟云学术

Impact of Ferroquine on the Solubilization of Artefenomel (OZ439) during in Vitro Lipolysis in Milk and Implications for Oral Combination Therapy for Malaria

Published:2019-03-04 Issue:4 Volume:16 Page:1658-1668
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Salim Malinda¹,Khan Jamal¹,Ramirez Gisela¹,Murshed Mubtasim¹,Clulow Andrew J.¹^ORCID,Hawley Adrian²,Ramachandruni Hanu³,Beilles Stephane⁴,Boyd Ben J.¹⁵^ORCID

Affiliation:

1. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia

2. SAXS/WAXS Beamline, Australian Synchrotron, ANSTO, 800 Blackburn Road, Clayton, VIC 3169, Australia

3. Medicines for Malaria Venture, 20, Route de Pré-Bois, 1215 Geneva 15, Switzerland

4. Sanofi R&D, 371 Rue du Professeur Blayac, 34080 Montpellier, France

5. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia

Funder

Bill and Melinda Gates Foundation

Australian Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.8b01333

Reference36 articles.

1. The Effects of Food on the Dissolution of Poorly Soluble Drugs in Human and in Model Small Intestinal Fluids

2. Healthy Volunteer Study of the Pharmacokinetics of Oral Piperaquine With OZ439 + TPGS Formulation in the Fasted State, https://clinicaltrials.gov/ct2/show/study/NCT01853475, accessed February 27, 2019.

3. Evaluation of the QT effect of a combination of piperaquine and a novel anti‐malarial drug candidate OZ439, for the treatment of uncomplicated malaria

4. The impact of digestion is essential to the understanding of milk as a drug delivery system for poorly water soluble drugs

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