Influence of Arginine Salts on the Thermal Stability and Aggregation Kinetics of Monoclonal Antibody: Dominant Role of Anions
Author:
Affiliation:
1. Department of Drug Device and Delivery Development, Biopharmaceutical Development, MedImmune LLC, Gaithersburg, Maryland 20878, United States
2. Cura Point LLC, 2000 Cal Young Road, Suite D, Eugene, Oregon 97401, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.6b00255
Reference27 articles.
1. Role of Arginine in the Stabilization of Proteins against Aggregation
2. Effect of Arginine on Protein Aggregation Studied by Fluorescence Correlation Spectroscopy and Other Biophysical Methods
3. Role of Arginine in Protein Refolding, Solubilization, and Purification
4. A Simple Method for Improving Protein Solubility and Long-Term Stability
5. Arginine inhibits aggregation of α-lactalbumin but also decreases its stability: Calorimetric, spectroscopic, and molecular dynamics studies
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