Advancing Therapeutic Protein Discovery and Development through Comprehensive Computational and Biophysical Characterization-Reference-Cited by-同舟云学术

Advancing Therapeutic Protein Discovery and Development through Comprehensive Computational and Biophysical Characterization

Published:2020-01-07 Issue: Volume: Page:
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Gentiluomo Lorenzo¹²^ORCID,Svilenov Hristo L.²^ORCID,Augustijn Dillen³,El Bialy Inas²,Greco Maria Laura⁴,Kulakova Alina⁵^ORCID,Indrakumar Sowmya⁵,Mahapatra Sujata⁶,Morales Marcello Martinez⁴,Pohl Christin⁶,Roche Aisling⁷,Tosstorff Andreas²,Curtis Robin⁷^ORCID,Derrick Jeremy P.⁸^ORCID,Nørgaard Allan⁶,Khan Tarik A.⁹,Peters Günther H. J.⁵^ORCID,Pluen Alain⁷,Rinnan Åsmund³^ORCID,Streicher Werner W.⁶,van der Walle Christopher F.⁴^ORCID,Uddin Shahid⁴,Winter Gerhard²,Roessner Dierk¹,Harris Pernille⁵^ORCID,Frieß Wolfgang²

Affiliation:

1. Wyatt Technology Europe GmbH, Hochstrasse 18, 56307 Dernbach, Germany

2. Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universitaet Muenchen, Butenandtstrasse 5, 81377 Munich, Germany

3. Department of Food Science, Faculty of Science, Copenhagen University, Rolighedsvej 26, 1958 Frederiksberg, Denmark

4. Dosage Form Design and Development, AstraZeneca, Sir Aaron Klug Building, Granta Park, Cambridge CB21 6GH, U.K.

5. Department of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kongens Lyngby, Denmark

6. Novozymes A/S, Krogshoejvej 36, 2880 Bagsvaerd, Denmark

7. School of Chemical Engineering and Analytical Science, Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.

8. School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester M13 9PT, U.K.

9. Pharmaceutical Development & Supplies, Pharma Technical Development Biologics Europe, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland

Funder

EU Horizon 2020 Research and Innovation program

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.9b00852

Reference64 articles.

1. Therapeutic Proteins

2. Discovery and development of biopharmaceuticals: current issues

3. Developability Assessment During the Selection of Novel Therapeutic Antibodies