Molecular-Level Structural Analysis of siRNA-Loaded Lipid Nanoparticles by <sup>1</sup>H NMR Relaxometry: Impact of Lipid Composition on Their Structural Properties-Reference-Cited by-同舟云学术

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Molecular-Level Structural Analysis of siRNA-Loaded Lipid Nanoparticles by ¹H NMR Relaxometry: Impact of Lipid Composition on Their Structural Properties

Published:2023-08-22 Issue:9 Volume:20 Page:4729-4742
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Ueda Keisuke¹^ORCID,Sakagawa Yui¹,Saito Tomoki¹,Fujimoto Taiki¹,Nakamura Misaki¹,Sakuma Fumie¹,Kaneko Shun¹,Tokumoto Taisei¹,Nishimura Koki²,Takeda Junpei²^ORCID,Arai Yuta¹²^ORCID,Yamamoto Katsuhiko¹²,Ikeda Yukihiro¹²,Higashi Kenjirou¹^ORCID,Moribe Kunikazu¹^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan

2. Analytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, 2-26-1, Muraoka-Higashi, Fujisawa, Kanagawa 251-8555, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.3c00477

Reference56 articles.

1. Lipid Nanoparticles as Delivery Systems for RNA-Based Vaccines

2. Lipid nanoparticles for mRNA delivery

3. Lipid Nanoparticle–mRNA Formulations for Therapeutic Applications

4. Difference in the lipid nanoparticle technology employed in three approved siRNA (Patisiran) and mRNA (COVID-19 vaccine) drugs

5. RNA-based therapeutics: an overview and prospectus

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