Novel Hydrophilic Camptothecin Derivatives Conjugated to Branched Glycerol Trimer Suppress Tumor Growth without Causing Diarrhea in Murine Xenograft Models of Human Lung Cancer-Reference-Cited by-同舟云学术

Novel Hydrophilic Camptothecin Derivatives Conjugated to Branched Glycerol Trimer Suppress Tumor Growth without Causing Diarrhea in Murine Xenograft Models of Human Lung Cancer

Published:2020-02-18 Issue:4 Volume:17 Page:1049-1058
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Tsuchihashi Yuki¹,Abe Shinji²,Miyamoto Licht¹³^ORCID,Tsunematsu Honoka¹,Izumi Toshihiro²,Hatano Aya¹,Okuno Hiroko¹,Yamane Megumi¹,Yasuoka Takashi¹,Ikeda Yasumasa⁴,Tsuchiya Koichiro¹

Affiliation:

1. Department of Medical Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan

2. Department of Clinical Pharmacy Practice Pedagogy, Institute of Biomedical Sciences, Graduate School of Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan

3. Department of Bioorganic Synthetic Chemistry, Institute of Biomedical Sciences, Graduate School of Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan

4. Department of Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University, 3-18-15, Kuramoto-cho, Tokushima 770-8505, Japan

Funder

Japan Science and Technology Agency

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.9b00249

Reference30 articles.

1. Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2

2. Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

3. CPT-11 Converting Enzyme from Rat Serum: Purification and Some Properties.

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