Nanoencapsulation of MDM2 Inhibitor RG7388 and Class-I HDAC Inhibitor Entinostat Enhances their Therapeutic Potential Through Synergistic Antitumor Effects and Reduction of Systemic Toxicity-Reference-Cited by-同舟云学术

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Nanoencapsulation of MDM2 Inhibitor RG7388 and Class-I HDAC Inhibitor Entinostat Enhances their Therapeutic Potential Through Synergistic Antitumor Effects and Reduction of Systemic Toxicity

Published:2024-02-09 Issue:3 Volume:21 Page:1246-1255
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Abed Anas¹²,Greene Michelle K.¹,Alsa’d Alhareth A.²³,Lees Andrea¹,Hindley Andrew⁴,Longley Daniel B¹,McDade Simon S¹,Scott Christopher J.¹^ORCID

Affiliation:

1. The Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7AE, United Kingdom

2. Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19111, Jordan

3. School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom

4. Clinical Haematology, Belfast City Hospital, 97 Lisburn Road, Belfast, BT9 7AB, United Kingdom

Funder

Al-Ahliyya Amman University

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.3c00926

Reference36 articles.

1. p53 Ubiquitination: Mdm2 and Beyond

2. How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

3. In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

4. Clinical Overview of MDM2/X-Targeted Therapies

5. Reactivation of p53 gene by MDM2 inhibitors: A novel therapy for cancer treatment

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