Combining Scattering Experiments and Colloid Theory to Characterize Charge Effects in Concentrated Antibody Solutions-Reference-Cited by-同舟云学术

Combining Scattering Experiments and Colloid Theory to Characterize Charge Effects in Concentrated Antibody Solutions

Published:2024-04-25 Issue:5 Volume:21 Page:2250-2271
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Gulotta Alessandro¹,Polimeni Marco¹^ORCID,Lenton Samuel¹,Starr Charles G.²,Stradner Anna¹³^ORCID,Zaccarelli Emanuela⁴⁵^ORCID,Schurtenberger Peter¹³^ORCID

Affiliation:

1. Physical Chemistry, Department of Chemistry, Lund University, Lund SE-221 00, Sweden

2. Biologics Drug Product Development and Manufacturing, CMC Development, Sanofi, Framingham, Massachusetts 01701, United States

3. LINXS Institute of Advanced Neutron and X-ray Science, Scheelevägen 19, Lund SE-223 70, Sweden

4. Institute for Complex Systems, National Research Council (ISC−CNR), Piazzale Aldo Moro 5, Rome 00185, Italy

5. Department of Physics, Sapienza University of Rome, Piazzale Aldo Moro 2, Rome 00185, Italy

Funder

Vetenskapsr?det

Sanofi

H2020 Research Infrastructures

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.3c01023

Reference77 articles.

1. A single molecular descriptor to predict solution behavior of therapeutic antibodies

2. The Role of Electrostatics in Protein–Protein Interactions of a Monoclonal Antibody

3. IgG Charge: Practical and Biological Implications

4. Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies

5. The Influence of Charge Distribution on Self-Association and Viscosity Behavior of Monoclonal Antibody Solutions