A Novel Doxorubicin Prodrug with GRP78 Recognition and Nucleus-Targeting Ability for Safe and Effective Cancer Therapy-Reference-Cited by-同舟云学术

A Novel Doxorubicin Prodrug with GRP78 Recognition and Nucleus-Targeting Ability for Safe and Effective Cancer Therapy

Published:2017-12-15 Issue:1 Volume:15 Page:238-246
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Ding Guo-Bin¹²^ORCID,Sun Junqing¹²,Yang Peng¹²,Li Binchun¹^ORCID,Gao Ying³,Li Zhuoyu¹²³

Affiliation:

1. Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China

2. Institutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, China

3. School of Life Science, Shanxi University, Taiyuan 030006, China

Funder

National Natural Science Foundation of China

Shanxi Scholarship Council of China

Scientific and Technologial Innovation Programs of Higher Education Institutions in Shanxi Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.7b00830

Reference36 articles.

1. Glucose regulated protein 78: A critical link between tumor microenvironment and cancer hallmarks

2. Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting

3. Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction

4. Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface–Associated GRP78

5. Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78

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