Multidrug Efflux Pumps Attenuate the Effect of MGMT Inhibitors
Author:
Affiliation:
1. Department of Toxicology, University Medical Center, Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany
2. Montreal Neurological Hospital and Institute, 3801 University Street, Montréal, Quebec H3A 2B4, Canada
Funder
Deutsche Forschungsgemeinschaft
Universitätsmedizin, Johannes Gutenberg-Universität Mainz
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.5b00341
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1. Balancing repair and tolerance of DNA damage caused by alkylating agents
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3. Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles
4. Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides
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