Practical Synthesis of [18F]Pitavastatin and Evaluation of Hepatobiliary Transport Activity in Rats by Positron Emission Tomography-Reference-Cited by-同舟云学术

Practical Synthesis of [18F]Pitavastatin and Evaluation of Hepatobiliary Transport Activity in Rats by Positron Emission Tomography

Published:2020-04-09 Issue:6 Volume:17 Page:1884-1898
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Nakaoka Takayoshi¹²^ORCID,Uetake Yuta¹^ORCID,Kaneko Ken-ichi¹²,Niwa Takashi¹²^ORCID,Ochiai Hidenori¹,Irie Satsuki¹²,Suezaki Yoshie¹²,Otsuka Natsumi¹,Hayashinaka Emi¹²,Wada Yasuhiro¹²,Cui Yilong¹²,Maeda Kazuya³,Kusuhara Hiroyuki³,Sugiyama Yuichi⁴,Hosoya Takamitsu¹²⁵^ORCID,Watanabe Yasuyoshi¹²

Affiliation:

1. RIKEN Center for Life Science Technologies (CLST), 6-7-3 minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan

2. RIKEN Center for Biosystems Dynamics Research (BDR), 6-7-3 minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan

3. Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

4. Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan

5. Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan

Funder

RIKEN

Japan Agency for Medical Research and Development

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.9b01284

Reference46 articles.

1. In vitro-in vivo Extrapolation of Transporter-mediated Clearance in the Liver and Kidney

2. Investigation of the Rate-Determining Process in the Hepatic Elimination of HMG-CoA Reductase Inhibitors in Rats and Humans

3. Studies on the Metabolic Fate of NK-104, a New Inhibitor of HMG-CoA Reductase (1) : Absorption, Distribution, Metabolism and Excretion in Rats

4. Studies on the Metabolic Fate of NK-104, a New Inhibitor of HMG-CoA Reductase. (2). Absorption, Distribution, Metabolism, Excretion and Accumulation Following Repeated Oral Administration of 14C-NK-104 in Rats.

5. Studies on the Metabolic Fate of NK-104, a New Inhibitor of HMG-CoA Reductase. (5). In Vitro Metabolism and Plasma Protein Binding in Animals and Human.

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