Deamidation Can Compromise Antibody Colloidal Stability and Enhance Aggregation in a pH-Dependent Manner-Reference-Cited by-同舟云学术

Deamidation Can Compromise Antibody Colloidal Stability and Enhance Aggregation in a pH-Dependent Manner

Published:2019-03-27 Issue:5 Volume:16 Page:1939-1949
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Alam Magfur E.¹,Barnett Gregory V.²,Slaney Thomas R.²,Starr Charles G.³,Das Tapan K.²,Tessier Peter M.¹³^ORCID

Affiliation:

1. Isermann Department of Chemical & Biological Engineering, Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, United States

2. Biologics Development, Bristol-Myers Squibb, Pennington, New Jersey 08534, United States

3. Departments of Chemical Engineering, Pharmaceutical Sciences and Biomedical Engineering, Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48109, United States

Funder

Bristol-Myers Squibb

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.8b01311

Reference43 articles.

1. The therapeutic monoclonal antibody market

2. Development trends for human monoclonal antibody therapeutics

3. The Increasingly Human and Profitable Monoclonal Antibody Market