Understanding the Influence of API Conformations on Amorphous Dispersion Formation Potential Predictions using the <i>R</i>3<i>m</i> Molecular Descriptor-Reference-Cited by-同舟云学术

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Understanding the Influence of API Conformations on Amorphous Dispersion Formation Potential Predictions using the R3m Molecular Descriptor

Published:2024-01-05 Issue:2 Volume:21 Page:770-780
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

DeBoyace Kevin¹²,Bookwala Mustafa¹,Zhou Deliang³⁴^ORCID,Buckner Ira S.¹,Wildfong Peter L.D.¹^ORCID

Affiliation:

1. School of Pharmacy and Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Ave, Pittsburgh, Pennsylvania 15282, United States

2. Pfizer Worldwide R&D, Eastern Point Road, Groton, Connecticut 06340, United States

3. Drug Product Development, Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States

4. Small Molecules Drug Product Development, BeiGene USA, Inc., 55 Cambridge Parkway, Cambridge, Massachusetts 02142, United States

Funder

AbbVie

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.3c00909

Reference40 articles.

1. The Implications of Drug-Polymer Interactions on the Physical Stability of Amorphous Solid Dispersions

2. Analysis of the Literature and Patents on Solid Dispersions from 1980 to 2015

3. Innovations in Thermal Processing: Hot-Melt Extrusion and KinetiSol® Dispersing

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