Anti-PEG IgM Is a Major Contributor to the Accelerated Blood Clearance of Polyethylene Glycol-Conjugated Protein-Reference-Cited by-同舟云学术

Anti-PEG IgM Is a Major Contributor to the Accelerated Blood Clearance of Polyethylene Glycol-Conjugated Protein

Published:2015-06-24 Issue:7 Volume:12 Page:2429-2435
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Mima Yu¹,Hashimoto Yosuke¹,Shimizu Taro¹,Kiwada Hiroshi¹,Ishida Tatsuhiro¹

Affiliation:

1. Department of Pharmacokinetics and Biopharmaceutics, Institute of Health Biosciences, Tokushima University, 1-78-1 Sho-machi, Tokushima 770-8505, Japan

Funder

University of Tokushima

Takeda Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.5b00144

Reference47 articles.

1. Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol.

2. Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo

3. PEGylation of therapeutic proteins

4. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

5. Pharmacokinetic and biodistribution properties of poly(ethylene glycol)–protein conjugates

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