Direct Visualization of Drug–Polymer Phase Separation in Ritonavir–Copovidone Amorphous Solid Dispersions Using in situ Synchrotron X-ray Fluorescence Imaging of Thin Films-Reference-Cited by-同舟云学术

Direct Visualization of Drug–Polymer Phase Separation in Ritonavir–Copovidone Amorphous Solid Dispersions Using in situ Synchrotron X-ray Fluorescence Imaging of Thin Films

Published:2019-09-25 Issue:11 Volume:16 Page:4751-4754
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Shi Chenyang¹^ORCID,Li Luxi²,Zhang Geoff G. Z.¹,Borchardt Thomas B.¹

Affiliation:

1. Drug Product Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States

2. Advanced Photon Sources, Argonne National Laboratory, 9700 Cass Avenue, Lemont, Illinois 60439, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.9b00651

Reference18 articles.

1. Pharmaceutical Applications of Solid Dispersion Systems

2. Solid dispersion of poorly water‐soluble drugs: Early promises, subsequent problems, and recent breakthroughs

3. Ritonavir–PEG 8000Amorphous Solid Dispersions: In vitro and In vivo Evaluations

4. Amorphous pharmaceutical solids: preparation, characterization and stabilization

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