Gaining Insight into the Role of the Solvent during Spray Drying of Amorphous Solid Dispersions by Studying Evaporation Kinetics-Reference-Cited by-同舟云学术

Gaining Insight into the Role of the Solvent during Spray Drying of Amorphous Solid Dispersions by Studying Evaporation Kinetics

Published:2022-04-01 Issue:5 Volume:19 Page:1604-1618
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Dedroog Sien¹,Adriaensens Peter²,Van den Mooter Guy¹^ORCID

Affiliation:

1. Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Campus Gasthuisberg ON2, Herestraat 49 b921, Leuven 3000, Belgium

2. Applied and Analytical Chemistry, Institute for Materials Research, Hasselt University, Agoralaan 1-Building D, Diepenbeek 3590, Belgium

Funder

Universiteit Hasselt

Fonds Wetenschappelijk Onderzoek

Laboratoires SMB

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.2c00095

Reference31 articles.

1. Pharmaceutical Applications of Solid Dispersion Systems

2. Spray drying formulation of amorphous solid dispersions

3. Influence of solvent evaporation rate and formulation factors on solid dispersion physical stability

4. Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: Formulation and process considerations

5. The underestimated contribution of the solvent to the phase behavior of highly drug loaded amorphous solid dispersions

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