Visible Light Degradation of a Monoclonal Antibody in a High-Concentration Formulation: Characterization of a Tryptophan-Derived Chromophoric Photo-product by Comparison to Photo-degradation of N-Acetyl-l-tryptophan Amide-Reference-Cited by-同舟云学术

Visible Light Degradation of a Monoclonal Antibody in a High-Concentration Formulation: Characterization of a Tryptophan-Derived Chromophoric Photo-product by Comparison to Photo-degradation of N-Acetyl-l-tryptophan Amide

Published:2021-08-16 Issue:9 Volume:18 Page:3223-3234
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Prajapati Indira¹²,Larson Nicholas R.¹^ORCID,Choudhary Sureshkumar²,Kalonia Cavan²,Hudak Suzanne²,Esfandiary Reza²,Middaugh C. Russell¹,Schöneich Christian¹^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, University of Kansas, 2093 Constant Avenue, Lawrence, Kansas 66047, United States

2. Dosage Form Design and Development, BioPharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland 20878, United States

Funder

MedImmune

National Institutes of Health

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.1c00043

Reference51 articles.

1. Monoclonal antibody successes in the clinic

2. Monoclonal antibody therapeutics: history and future

3. Potent antibody therapeutics by design

4. Characterization of the Degradation Products of a Color-Changed Monoclonal Antibody: Tryptophan-Derived Chromophores

5. Challenges in the development of high protein concentration formulations

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