Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3)-Reference-Cited by-同舟云学术

Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3)

Published:2015-11-16 Issue:12 Volume:12 Page:4301-4310
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Liang Xiaomin¹,Chien Huan-Chieh¹,Yee Sook Wah¹,Giacomini Marilyn M.²,Chen Eugene C.¹,Piao Meiling¹³,Hao Jia²,Twelves Jolyn²,Lepist Eve-Irene²,Ray Adrian S.²,Giacomini Kathleen M.¹

Affiliation:

1. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, United States

2. Department of Drug Metabolism, Gilead Sciences, Inc., Foster City, California 94404, United States

3. Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China

Funder

China Scholarship Council

Burroughs Wellcome Fund

U.S. Food and Drug Administration

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.5b00501

Reference43 articles.

1. Metformin action on AMP-activated protein kinase: a translational research approach to understanding a potential new therapeutic target

2. Metformin: an old but still the best treatment for type 2 diabetes

3. Long-Term Effects of Metformin and Lifestyle Modification on Nonalcoholic Fatty Liver Disease Obese Adolescents

4. Clinical Pharmacokinetics of Metformin

5. Reduced Hepatic Uptake and Intestinal Excretion of Organic Cations in Mice with a Targeted Disruption of the Organic Cation Transporter 1 ( Oct1 [ Slc22a1 ]) Gene

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