A Nanoparticle-Based Assay To Evaluate Surface-Induced Antibody Instability
Author:
Affiliation:
1. Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, Zurich 8093, Switzerland
Funder
Eidgen?ssische Technische Hochschule Z?rich
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.9b01168
Reference58 articles.
1. Protein Instability and Immunogenicity: Roadblocks to Clinical Application of Injectable Protein Delivery Systems for Sustained Release
2. Mouse Models for Assessing Protein Immunogenicity: Lessons and Challenges
3. Driving Forces for Nonnative Protein Aggregation and Approaches to Predict Aggregation-Prone Regions
4. Understanding and overcoming trade-offs between antibody affinity, specificity, stability and solubility
5. Native-State Solubility and Transfer Free Energy as Predictive Tools for Selecting Excipients to Include in Protein Formulation Development Studies
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