Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics-Reference-Cited by-同舟云学术

Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics

Published:2019-07-26 Issue:9 Volume:16 Page:3968-3976
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Heikkinen Emma M.^ORCID,Auriola Seppo,Ranta Veli-Pekka,Demarais Nicholas J.¹^ORCID,Grey Angus C.²,del Amo Eva M.³,Toropainen Elisa,Vellonen Kati-Sisko,Urtti Arto⁴⁵^ORCID,Ruponen Marika

Affiliation:

1. School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

2. University of Auckland, School of Medical Sciences, Department of Physiology, Private Bag 92019, Auckland 1142, New Zealand

3. School of Health Sciences, Division of Pharmacy & Optometry, University of Manchester, Oxford Road, Manchester M13 9PL, U.K.

4. Faculty of Pharmacy, Division of Pharmaceutical Biosciences, University of Helsinki, Viikinkaari, Helsinki 00014, Finland

5. Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Prospect, Saint Petersburg 198504, Russia

Funder

H2020 Marie Sklodowska-Curie Actions

P?ivikki ja Sakari Sohlbergin S??ti?

Biotieteiden ja Ymp?rist?n Tutkimuksen Toimikunta

Doctoral Programme in Drug Research

Biocenter Finland

Biocenter Kuopio

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.9b00585

Reference34 articles.

1. Permeability of the Anterior Lens Capsule for Large Molecules and Small Drugs

2. Determination of human lens capsule permeability and its feasibility as a replacement for Bruch's membrane

3. Characterizing molecular diffusion in the lens capsule

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