Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells

Author:

van Gisbergen Marike W.12,Cebula Marcus1,Zhang Jie13,Ottosson-Wadlund Astrid1,Dubois Ludwig2,Lambin Philippe2,Tew Kenneth D.3,Townsend Danyelle M.4,Haenen Guido R. M. M.5,Drittij-Reijnders Marie-José5,Saneyoshi Hisao6,Araki Mika6,Shishido Yuko7,Ito Yoshihiro6,Arnér Elias S. J.8,Abe Hiroshi67,Morgenstern Ralf1,Johansson Katarina8

Affiliation:

1. Institute of Environmental Medicine, Division of Biochemical Toxicology, Karolinska Institutet, SE 17177 Stockholm, Sweden

2. Department of Radiation Oncology (MaastRO Lab), GROW—School for Oncology and Developmental Biology, Maastricht University Medical Center, Universiteitssingel 50/23, PO Box 616, 6200 MD Maastricht, The Netherlands

3. Departments of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina 29425, United States

4. Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, United States

5. Department of Toxicology, NUTRIM—School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Center, Universiteitssingel 50/23, PO Box 616, 6200 MD Maastricht, The Netherlands

6. Nano Medical Engineering Laboratory, Discovery Research Institute, RIKEN 2-1, Hirosawa, Wako-Shi, Saitama 351-0198, Japan

7. Department of Chemistry, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan

8. Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden

Funder

AstraZeneca

Universiteit Maastricht

Karolinska Institutet

Carl Tryggers Foundation for Scientific Research, Sweden

New Energy and Industrial Technology Development Organization (NEDO), Japan

The Swedish research council

Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan

Swedish foundation for strategic research (SSF)

The Swedish Cancer Society

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Cited by 24 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3