Isotope-Edited Infrared Spectroscopy for Efficient Discrimination between Pharmaceutical Salts and Cocrystals
Author:
Affiliation:
1. Analytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, 2-26-1, Muraoka-Higashi, Fujisawa, Kanagawa 251-8555, Japan
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.7b00226
Reference47 articles.
1. Pharmaceutical Cocrystals and Their Physicochemical Properties
2. Pharmaceutical cocrystals: along the path to improved medicines
3. Guidance for Industry: Regulatory Classification of Pharmaceutical Co-crystals;U.S. FDA:Silver Spring, MD, 2016.http://www.fda.gov/downloads/Drugs/Guidances/UCM516813.pdf.
4. Reflection paper on the use of cocrystals of active substances in medicinal products; E.U. EMA: EMA/CHMP/CVMP/QWP/284008/2015, 2015.http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2015/07/WC500189927.pdf.
5. The Salt−Cocrystal Continuum: The Influence of Crystal Structure on Ionization State
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