Semimechanistic Population Pharmacokinetic Modeling to Investigate Amyloid Beta Trafficking and Accumulation at the BBB Endothelium-Reference-Cited by-同舟云学术

Semimechanistic Population Pharmacokinetic Modeling to Investigate Amyloid Beta Trafficking and Accumulation at the BBB Endothelium

Published:2021-10-19 Issue:11 Volume:18 Page:4148-4161
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Wang Zengtao¹,Sharda Nidhi¹,Curran Geoffry L.²,Li Ling³,Lowe Val J.²,Kandimalla Karunya K.¹^ORCID

Affiliation:

1. Department of Pharmaceutics and Brain Barriers Research Center, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United Sates

2. Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, United Sates

3. Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United Sates

Funder

Minnesota Partnership for Biotechnology and Medical Genomics

National Institutes of Health National Institute on Aging

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.1c00549

Reference57 articles.

1. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

2. Differences Between Vascular and Plaque Core Amyloid in Alzheimer's Disease

3. Total Aβ42/Aβ40ratio in plasma predicts amyloid-PET status, independent of clinical AD diagnosis

4. Neurochemical diagnosis of Alzheimer’s dementia by CSF Aβ42, Aβ42/Aβ40 ratio and total tau

5. Alzheimer's Disease: Genes, Proteins, and Therapy

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Liver as a new target organ in Alzheimer’s disease: insight from cholesterol metabolism and its role in amyloid-beta clearance;Neural Regeneration Research;2023-12-21

2. A mathematical model on Aβ blood–brain transport: Simulations of plaques’ formation in Alzheimer’s disease;Medical Hypotheses;2023-12

3. Amyloid-Beta Peptides 40 and 42 Employ Distinct Molecular Pathways for Cell Entry and Intracellular Transit at the Blood–Brain Barrier Endothelium;Molecular Pharmacology;2023-08-04

4. Effect of β-amyloid on blood-brain barrier properties and function;Biophysical Reviews;2023-04

5. Amyloid-beta peptides 40 and 42 employ distinct molecular pathways for cell entry and intracellular transit at the BBB endothelium;2022-11-18