Identification and Strategies to Mitigate High Total Clearance of Benzylamine-Substituted Biphenyl Ring Systems-Reference-Cited by-同舟云学术

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Identification and Strategies to Mitigate High Total Clearance of Benzylamine-Substituted Biphenyl Ring Systems

Published:2022-05-09 Issue:7 Volume:19 Page:2115-2132
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Williamson Beth¹,McMurray Lindsay²,Boyd Scott²,Collingwood Olga²,McLean Neville²,Winter-Holt Jon²^ORCID,Chan Christina¹,Xue Aixiang³,McCoull William²^ORCID

Affiliation:

1. Drug Metabolism and Pharmacokinetics, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK

2. Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK

3. R&D Clinical Pharmacology and Safety Sciences, AstraZeneca, Waltham 02451, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.2c00014

Reference28 articles.

1. Further Considerations Towards an Effective and Efficient Oncology Drug Discovery DMPK Strategy

2. Prevalence of Non-Cytochrome P450-Mediated Metabolism in Food and Drug Administration-Approved Oral and Intravenous Drugs: 2006-2015

3. Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

4. Clearance concepts in pharmacokinetics

5. Evaluation of the Disconnect between Hepatocyte and Microsome Intrinsic Clearance and In Vitro In Vivo Extrapolation Performance

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