Impact of Drug Conjugation and Loading on Target Antigen Binding and Cytotoxicity in Cysteine Antibody–Drug Conjugates-Reference-Cited by-同舟云学术

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Impact of Drug Conjugation and Loading on Target Antigen Binding and Cytotoxicity in Cysteine Antibody–Drug Conjugates

Published:2021-01-20 Issue:3 Volume:18 Page:889-897
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Nadkarni Durgesh V.¹^ORCID,Lee Jamie²,Jiang Qingping³,Patel Vimalkumar¹,Sriskanda Verl³,Dutta Kaushik¹,Meyer Debra M.²

Affiliation:

1. Bioprocess Research and Development, Pfizer Inc., 401 N. Middletown Road, Pearl River, New York 10965, United States

2. Analytical Research and Development, Pfizer Inc., 875 Chesterfield Parkway West, Chesterfield, Missouri 63017, United States

3. Analytical Research and Development, Pfizer Inc., 401 N. Middletown Road, Pearl River, New York 10965, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.0c00873

Reference16 articles.

1. Antibody Conjugates-Recent Advances and Future Innovations

2. Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads

3. A personal perspective of the development and validation of a phase-specific antibody–drug conjugate cytotoxicity potency assay

4. Bioanalytical assay strategies for the development of antibody–drug conjugate biotherapeutics

5. Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate

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4. Polymersome Membrane Engineering with Active Targeting or Controlled Permeability for Responsive Drug Delivery;Biomacromolecules;2023-10-23

5. Organic‐Solvent‐Free “Lego‐Like” Modular Preparation of Fab‐Nondestructive Antibody‐Drug Conjugates with Ultrahigh Drug‐to‐Antibody Ratio;Advanced Materials;2023-10-15

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