Influence of PLGA End Groups on the Release Profile of Dexamethasone from Ocular Implants

Author:

Saraf Isha1,Kushwah Varun1,Alva Carolina1,Koutsamanis Ioannis1,Rattenberger Johannes2,Schroettner Hartmuth23,Mayrhofer Claudia2,Modhave Dattatray1,Braun Michael4,Werner Bernd5,Zangger Klaus5ORCID,Paudel Amrit16ORCID

Affiliation:

1. Research Centre for Pharmaceutical Engineering, Inffeldgasse 13/2, Graz8010, Austria

2. Graz Centre for Electron Microscopy (ZFE), Steyrergasse 17, Graz8010, Austria

3. Institute of Electron Microscopy and Nanoanalysis (FELMI), NAWI Graz, Graz University of Technology, Steyrergasse 17, Graz8010, Austria

4. Pharmaceutical Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach88397, Germany

5. Institute of Chemistry, University of Graz, Heinrichstr. 28, Graz8010, Austria

6. Institute for Process and Particle Engineering, Graz University of Technology, Inffeldgasse 13/3, Graz8010, Austria

Funder

The authors acknowledge Eduardo Machado Charry and Robert Schennach for support with ?-CT measurements.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Reference51 articles.

1. Dexamethasone Intravitreal Implant in Patients with Macular Edema Related to Branch or Central Retinal Vein Occlusion

2. Dexamethasone Intravitreal Implant for Noninfectious Intermediate or Posterior Uveitis

3. DEXAMETHASONE INTRAVITREAL IMPLANT FOR TREATMENT OF DIABETIC MACULAR EDEMA IN VITRECTOMIZED PATIENTS

4. OZURDEX ® (Dexamethasone) 700 Mg Intravitreal Implant CMI V3.0 OZURDEX ® (Dexamethasone) 700 Mg Intravitreal Implant.

5. Shiah, J. G.; Bhagat, R.; Blanda, W. M.; Nivaggioli, T.; Peng, L.; Chou, D.; Weber, D. A.Ocular Implant Made by a Double Extrusion Process. US8034366B22005.

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