Effect of ‘pH’ on the Rate of Pyroglutamate Formation in Solution and Lyophilized Solids-Reference-Cited by-同舟云学术

Effect of ‘pH’ on the Rate of Pyroglutamate Formation in Solution and Lyophilized Solids

Published:2021-07-07 Issue:8 Volume:18 Page:3116-3124
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Bersin Lia M.¹,Patel Sajal M.²,Topp Elizabeth M.¹³^ORCID

Affiliation:

1. Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907-2091, United States

2. Dosage Form Design & Development, Biopharmaceutical Development, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland 20878, United States

3. National Institute for Bioprocessing Research and Training, Belfield, Blackrock, County Dublin A94 X099, Ireland

Funder

AstraZeneca

Pharmaceutical Research and Manufacturers of America Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.1c00338

Reference33 articles.

1. Formation of Pyroglutamic Acid from N-Terminal Glutamic Acid in Immunoglobulin Gamma Antibodies

2. Investigation of N-terminal glutamate cyclization of recombinant monoclonal antibody in formulation development

3. Identification of N-terminal modification for recombinant monoclonal antibody light chain using partial reduction and quadrupole time-of-flight mass spectrometry

4. Glutaminyl Cyclases Display Significant Catalytic Proficiency for Glutamyl Substrates

5. Phosphate ions and glutaminyl cyclases catalyze the cyclization of glutaminyl residues by facilitating synchronized proton transfers

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