In Vivo Modulation of Cervicovaginal Drug Transporters and Tissue Distribution by Film-Released Tenofovir and Darunavir for Topical Prevention of HIV-1

Author:

Hijazi Karolin1ORCID,Iannelli Francesco2,Cuppone Anna Maria2,Desjardins Delphine3,Caldwell Anna4,Dereuddre-Bosquet Nathalie3,Scala Carlo5,Smith Kieron A.1,Mukhopadya Indrani1,Frank Bruce6,Gwozdz Garry6,Santoro Francesco2,Grand Roger Le3,Pozzi Gianni2,Kelly Charles5

Affiliation:

1. Institute of Dentistry, School of Medicine Medical Sciences & Nutrition, University of Aberdeen, Aberdeen AB25 2ZR, U.K.

2. Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, Siena 53100, Italy

3. Université Paris Sud, INSERM U1184−Immunology of Viral Infections and Autoimmune Diseases (IMVA), IDMIT Department, IBFJ, CEA, Fontenay-aux-Roses, France

4. Mass Spectrometry Facility, King’s College London, London SE1 9NH, U.K.

5. Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, London SE1 1UL, U.K.

6. Particle Sciences Inc., Lubrizol LifeSciences, Suite 180 Bethlehem, Pennsylvania 18017, United States

Funder

Agence Nationale de la Recherche

Seventh Framework Programme

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

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